|
Low dose ketamin
Made Wiryana1, I Ketut Sinardja2, I Gede Budiart2, Tjokorda Gde2, Agung Senapathi2, Made Widnyana2, I Wayan Aryabiantara2, I Gusti Agung Gede Utara Hartawan2, Pontisomaya Parami2, Ni Putu Adinda Putra Pradhana3, Adinda Putra Pradhana3
1 Professor, Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia
2 Senior Lecturer, Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia
3 Resident, Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia
Correspondence Address:
Ni Putu Adinda Putra Pradhana
Resident of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Kesehatan Street No 1 Denpasar-Bali
Indonesia
 Source of Support: None, Conflict of Interest: None
DOI: 10.15562/bjoa.v1i1.4
|
|
Ketamine binds non-competitive against a phencyclidine receptors bound N-methyl-D-aspartate (NMDA), a receptor that is involved in the pathophysiology of acute pain. Ketamine has been used as an intravenous anesthesia, analgesia for acute and chronic pain at a dose of subanaesthetic. Ketamine is a dissociative anesthetic produces a state with a characteristic strong analgesia, amnesia, and catalepsy. Dissociative components resulting from the effect on the limbic system and talamoneokortikal. Lowdose ketamine as known as analgesia dose ketamine or subanestesia dose is 0.2 to 0.75 mg / kg IV. At low doses, ketamine does not increase the effect psychomimetic like dissociation or deep sedation. The combination with midazolam provides satisfactory sedation, amnesia and analgesia without significant cardiovascular depression.
|
