Header bg
  • Users Online: 48
  • Print this page
  • Email this page
Header bg
Year : 2020  |  Volume : 4  |  Issue : 4  |  Page : 161-165

Comparison of nalbuphine versus fentanyl as an adjuvant to 0.75% isobaric ropivacaine in subarachnoid block for orthopedic surgery of lower limbs: A randomized, double-blind study

1 Department of Anaesthesiology, Dr. S N Medical College and Attached Hospitals, Jodhpur, Rajasthan, India
2 Department of Anaesthesiology, Divisional Railway Hospital, Jodhpur, Rajasthan, India
3 Department of Anaesthesiology, SMS Medical College and Attached Hospitals, Jaipur, Rajasthan, India

Correspondence Address:
Dr. Satveer Singh Gurjar
218-A, Pashupatinath Nagar, Pratapnagar, Jaipur - 302 033, Rajasthan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/BJOA.BJOA_112_20

Rights and Permissions

Background: Ropivacaine is an effective and safe alternative local anesthetic for subarachnoid block with a lesser duration of motor blockade and less neuro-cardiotoxicity. While fentanyl is commonly used as an adjuvant, nalbuphine recently got popular by its μ-attenuation and k-accentuation effects. We compared the efficacy of intrathecal fentanyl versus nalbuphine as an adjuvant to ropivacaine in subarachnoid block. Materials and Methods: In this prospective, randomized, double-blind study, seventy adult patients who were posted for elective lower limb orthopedic surgeries were randomly allocated to two groups. Group F received 22.5 mg of 0.75% isobaric ropivacaine with 25 μg fentanyl, and Group N received 22.5 mg of 0.75% isobaric ropivacaine with 1 mg nalbuphine intrathecally. Hemodynamics, onset, block duration, peak sensory level, two-segment regression time, and adverse effects such as nausea, vomiting, pruritus, sedation, hypotension, and bradycardia were studied. P < 0.05 was considered statistically significant. Results: Both groups achieved the target sensory level of T10. Time for onset of sensory and motor blockade, time to achieve peak sensory level, and motor block duration were statistically comparable in both groups. The duration of the sensory block was 254.45 ± 20.69 min in Group F and 297.4 ± 19.0 min in Group N (P < 0.001). The duration of analgesia was 275.6 ± 18.76 min in Group F and 318.2 ± 14.14 min in Group N (P < 0.001). Conclusions: Nalbuphine prolongs the duration of the sensory block along with the duration of postoperative analgesia in comparison to fentanyl as an intrathecal adjuvant to 0.75% isobaric ropivacaine for subarachnoid block.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded202    
    Comments [Add]    
    Cited by others 2    

Recommend this journal