Header bg
  • Users Online: 131
  • Print this page
  • Email this page
Header bg
REVIEW ARTICLE
Year : 2022  |  Volume : 6  |  Issue : 3  |  Page : 127-132

Comparison of oxycodone with morphine as adjuvant epidural analgesia and its side effects: A systematic review


Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Udayana, Bali, Indonesia

Correspondence Address:
Christopher Ryalino
Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Udayana, Jl. PB Sudirman, Denpasar 80232, Bali,
Indonesia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bjoa.bjoa_83_22

Rights and Permissions

Despite morphine’s ability to deliver effective analgesia, its use as an epidural adjuvant is limited by adverse effects such as nausea, vomiting, and pruritus, which are typically intractable with conventional antihistamines. Another negative effect that we are particularly concerned about is respiratory depression. This systematic review aimed to summarize the evidence based on randomized controlled trials (RCTs) comparing epidural analgesic adjuvants between oxycodone and morphine. We searched the Cochrane Library, PubMed, and EMBASE databases from 1990 until 2021 to find RCTs published in English language, which have investigated pain score and side effects such nausea and vomiting. Three RCTs were included in the final analysis. All of them employed similar argument that epidural analgesic with oxycodone has good analgesic effects at higher dose than morphine. Oxycodone provides analgesic properties equivalent to morphine, but with less nausea and vomiting. We found that epidural analgesic with oxycodone has comparable analgesic effect to morphine, as well as lower side effects on nausea and vomiting at twice morphine doses. Future study is needed to compare epidural oxycodone with morphine in terms of analgesia and adverse effects.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed530    
    Printed27    
    Emailed0    
    PDF Downloaded68    
    Comments [Add]    

Recommend this journal