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Year : 2022  |  Volume : 6  |  Issue : 3  |  Page : 157-161

Haloperidol vs. dexamethasone in lowering postoperative nausea and vomiting and pain in adult after laparoscopy: A randomized, double-blind study

Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Correspondence Address:
Aldy Heriwardito
Jati Palem No. 20, Jati, Pulo Gadung, Jakarta Timur, DKI Jakarta 13220
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bjoa.bjoa_101_22

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Background: The incidence of PONV (Postoperative Nausea and Vomiting) and pain are still one of the most common symptoms of post-surgery and prophylaxis to reduce the event is needed. Therefore, we wanted to know the effectiveness of 1 mg intravenous haloperidol compared to 5 mg intravenous dexamethasone to prevent the occurrence of nausea and vomiting and to control pain in adult patients after laparoscopic surgery. Materials and Methods: Eighty subjects (n = 40 for each group) scheduled for laparoscopic-assisted surgery were enrolled in a randomized double-blind clinical trial. One milligram intravenous haloperidol was given one hour before the end of surgery, while 5 mg intravenous dexamethasone was given right after induction. The occurrence of PONV and VAS pain score were recorded. Results: This study showed a significant difference in the incidence of nausea between haloperidol and dexamethasone at 2–6 hours (5% vs 25%, P = 0.012), 6–12 hours (10% vs 24%, P = 0.012), and 12–24 hours (12.5% vs 60%, P < 0.001) after laparoscopic surgery. The incidence of vomiting after laparoscopic surgery between two groups was not significantly different (P > 0,05). However, haloperidol group resulted in lower VAS pain score at every postoperative period with statistically significant result. Conclusion: The administration of 1 mg intravenous haloperidol is significantly better than 5 mg intravenous dexamethasone to prevent the occurrence of nausea and to lower the pain, but not significantly different to prevent the incidence of postoperative vomiting in adult patients after laparoscopic surgery.

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