Header bg
  • Users Online: 158
  • Print this page
  • Email this page
Header bg
Year : 2022  |  Volume : 6  |  Issue : 4  |  Page : 231-234

Multidrug-resistant organism infections correlate with increased mortality in COVID-19 patients: A retrospective, observational cohort study

1 Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Udayana, Bali, Indonesia
2 Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Udayana, Bali, Indonesia
3 Department of Microbiology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia

Correspondence Address:
I Wayan Sumardika
Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Udayana, Jl. PB Sudirman, Denpasar 80232, Bali
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bjoa.bjoa_181_22

Rights and Permissions

Background: The uncontrolled use of antibiotics is a big problem that will lead to antibiotic resistance. One of the recommendations for Corona Virus Disease 2019 (COVID-19) therapy is antibiotics. This study aimed to present the incidence of multidrug-resistant organism (MDRO) infections in COVID-19 patients and the risk of mortality in COVID-19 patients in the Indonesian population. Materials and Methods: A retrospective cohort study was conducted at a tertiary medical center in Indonesia. A total of 120 subjects were included in this study and divided equally into group M (COVID-19 patients with MDRO infections) and group N (without MDRO). The culture was conducted between the 17th and 10th days of treatment. A 2 × 2 table and chi-square test calculated the relative risk (RR) of MDRO causing mortality in COVID-19 patients. Results: The median age was 52 and 51 years old in groups M and N, respectively (P = 0.599). Based on the documented data related to microbiological culture to detect the types of microorganisms, carbapenem-resistant Acinetobacter baumannii was found to be the most MDRO isolated (30%), followed by extended-spectrum beta-lactamase (26.6%). Bivariate analysis showed that MDRO infection strongly correlates with the incidence of death with a RR of 4.167 (P < 0.001). Conclusion: MDRO infection is significantly correlated with mortality in COVID-19 patients. MDRO infections pose a four-fold chance of mortality compared to those without MDRO infections.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal